ONE MORNING THIS PAST SUMMER, I met Nir Barzilai, M.D., founding director of the Respect Toronto Blue Jays Official T-Shirt Apart from…,I will love this Institute for Aging Research at the Albert Einstein College of Medicine in New York, at the entrance of the three-mile pedestrian path of the Mario Cuomo Bridge, which stretches across the Hudson River. Affable and bespectacled, the 64-year-old author of the new book Age Later has suggested we exercise during our chat—exercise being one of the magic bullets for a long and vibrant life, or “health span,” as he and other experts term it. (When it comes to health span, Barzilai says, genetics account for only some 20 percent. The rest is environment and lifestyle.) On this morning, he has not yet broken his 16-hour life-lengthening daily fast. Research has also shown that “stressors” such as intermittent fasting can prompt your body to activate the genes that help repair broken DNA and protect chromosomes. As we walk, he takes me through his other practices: Along with his fasts and exercise, Barzilai takes a daily dose of metformin. An inexpensive diabetes medication that’s been around since the 1950s, metformin is thought to mimic the calorie restriction of fasting by limiting the amount of sugar the body absorbs (side effects are generally mild, among them abdominal pain, nausea, and loss of appetite). A 2017 study of more than 41,000 male metformin users found that it reduced—by a significant amount—the likelihood of dementia, cancer, and cardiovascular disease. A growing number of doctors are prescribing it off-label, but Barzilai wants the medication to be FDA-sanctioned for every elder adult. He’s about to undertake a six-year national trial (called TAME, for “Targeting Aging With Metformin”), partially and anonymously funded by a noted tech billionaire.
Respect Toronto Blue Jays Official T-Shirt, hoodie, tank top, sweater and long sleeve t-shirt
If fasting is not exactly your speed, diet is still tremendously important. As for what you should eat, the Respect Toronto Blue Jays Official T-Shirt Apart from…,I will love this gold standard remains the Mediterranean diet—one that is high in vegetables, fruits, whole grains, beans, nuts, seeds, and olive oil, and low on red meat—the only diet, says Barzilai, proven by clinical research to decrease cardiovascular mortality. A recent study in the medical journal Gut found that following it for just one year slowed the development of age-related inflammatory processes. David Sinclair, Ph.D., Harvard geneticist and author of the bestseller Lifespan: Why We Age—and Why We Don’t Have To, says the Mediterranean diet essentially “tricks the body into thinking we’ve been doing exercise and fasting.” Of course, this is not a permission slip for bottomless bowls of rigatoni; too much of a good thing is too much. Dan Buettner, the National Geographic Fellow who helped popularize the idea of the “blue zones”—the five areas worldwide with the longest-lived denizens—says he follows a rule practiced by the residents of Okinawa, Japan, and stops eating when his stomach is 80 percent full. And perhaps consider occasionally skipping dessert: Research shows that sugar intake accelerates age-related inflammation. “The more sugar you eat, the faster you age,” says Robert Lustig, professor of pediatric endocrinology at the University of California, San Francisco. (The American Heart Association recommends that women keep it under six teaspoons per day.)